NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on Oct 12, 2025.
Week 6 Plus-Money Bets
Last week's NFL bold predictions went 2-1, resulting in a +1.17 unit overall gain. Since Week 3, picks in this story are up 2.16 units.
This Week's Predictions
One potential strategy is fading the Colts offense, despite their strong performance. Indianapolis is currently averaging 3.39 points per drive, which would be the highest this century if maintained throughout the season.
Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here.
Author's summary: NFL Week 6 plus-money bets analysis.