Long-term Melatonin Use May Impact Heart Health
A review of five years of health records involving over 130,000 adults with chronic insomnia who used melatonin supplements for at least one year revealed concerning associations with heart health.
Key Findings from the Study
- Increased likelihood of being diagnosed with heart failure
- Higher rates of hospitalization due to heart failure
- Greater risk of death from any cause in individuals with chronic insomnia
This preliminary research was presented at the American Heart Association’s Scientific Sessions 2025, held from November 7 to 10 in New Orleans, highlighting new insights in cardiovascular science.
About Melatonin
Melatonin is a hormone naturally produced by the pineal gland in response to darkness, helping regulate the sleep-wake cycle. Synthetic melatonin supplements, chemically identical to the natural hormone, are commonly used to treat insomnia and jet lag.
These supplements are widely accessible over the counter in many countries, including the United States, where they do not require government approval for quality or consistency, leading to variations in strength and purity between brands.
"Long-term use of melatonin supplements, often used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization and death from any cause in chronic insomnia."
Author's summary: Prolonged melatonin supplement use for sleep issues may increase risks of heart failure and mortality, calling for caution and further research.