Long-Term Melatonin Use May Pose Heart Risks
New research highlights potential cardiovascular dangers associated with prolonged melatonin use. Individuals who chronically use melatonin for sleep issues were found to have nearly double the risk of death and a 3.5-fold increase in hospitalization due to heart failure.
Study Findings on Melatonin and Heart Health
A preliminary study presented at the American Heart Association's (AHA) Scientific Sessions 2025 revealed that adults suffering from chronic insomnia and taking melatonin for a year or longer faced higher chances of developing heart failure, being hospitalized for heart failure, and dying from any cause compared to non-users.
The results were unveiled at the AHA's annual meeting held from November 7 to 10 in New Orleans, a prominent event in cardiovascular science and clinical research.
About Melatonin
Melatonin is a hormone produced by the pineal gland that controls the body's sleep-wake cycle, increasing at night and decreasing during the day. Synthetic melatonin supplements, chemically identical to the natural hormone, are commonly used to treat insomnia and jet lag.
These supplements are available over the counter in many countries, including the United States. However, the lack of strict regulation in the U.S. leads to variations in product purity and dosage.
"Adults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement."
Expert Recommendations
Although melatonin is often viewed as safe, medical experts now advise caution regarding long-term use until further research confirms its safety profile.
Summary: Prolonged melatonin use for sleep disorders may increase the risk of heart failure and mortality, prompting experts to recommend cautious use of this commonly regarded safe hormone supplement.